In this episode of Annals On Call, Dr. Centor discusses the underuse of thiamine in critically ill patients with alcohol use disorder with Dr. Michael Donnino. Annals articles discussed include the Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness. A Nationwide Retrospective Observational Study: https://www.acpjournals.org/doi/10.7326/M21-2103
Here is the link to listen – https://www.acpjournals.org/doi/10.7326/A21-0023#.Y3LJ1Y8cLhw.twitter
Congratulations to our T32 fellow, Dr. Noa Berlin, for successfully obtaining a grant to study the inflammatory changes in pet dogs who have experienced natural cardiac arrest and compare it to people with similar conditions.
Supported by the American College of Veterinary Emergency and Critical Care (ACVECC) and the Reassessment Campaign on Veterinary Resuscitation (RECOVER) Initiative, we are excited to be collaborating with Tufts University on this pilot study, which will lay the groundwork for future translational research projects, in which dogs with naturally-occuring conditions can be used as models for human resuscitation research, and help advance both veterinary-and human medicine. We are excited for further collaborations in this field!
In our study of 40 patients with septic shock and tachycardia, we tested whether esmolol would reduce the need for vasopressors at 6h compared to placebo, as well as other outcomes. We found that there was no difference in vasopressor use at 6h or shock-free days between groups, but there were lower levels of C-reactive protein at 12 and 24 h in the esmolol arm, as well as a difference in trend over time between groups; there was no difference in levels of IL-4, IL-6, IL-10, and TNFα. We also found decreased oxygen consumption in the subset of patients who underwent VO2 monitoring when comparing esmolol to placebo. Here is the link to the study
Thiamine deficiency can cause irreversible brain damage if left untreated. Alcohol use is the most common risk factor of thiamine deficiency. Thiamine supplementation, the mainstay of treatment of thiamine deficiency, is safe, effective, and recommended by different scientific organizations while caring for patients with alcohol use. Despite that, thiamine supplementation is underutilized. We describe the incidence of thiamine supplementation in patients with alcohol use disorder admitted to ICU using the Cerner Database, a nationally representative dataset. We found that almost half such patients did not receive even a single dose of thiamine. Read more about this in our article published in Annals of Internal Medicine. Here is the link to the study
The authors are happy to contribute to the research on Covid-19 with their recently published study: Viral load and disease severity in COVID‑19
