Alumni

About Michael Cocchi

Dr. Cocchi currently practices as an attending physician in the emergency department and as an intensivist in the surgical intensive care units at BIDMC. After graduating from the University of Massachusetts Medical School, he completed his residency in Emergency Medicine at the Harvard Affiliated Emergency Medicine Residency at BIDMC, followed by a two-year fellowship in Critical Care Medicine. He is board certified in Emergency Medicine, Critical Care Medicine, and Neurocritical Care. His research interests have primarily focused on critical care topics, in particular cardiac arrest, sepsis, and shock. He is currently the Principal Investigator of a Phase II clinical trial studying the effects of esmolol in septic shock, funded by the American Heart Association. He is the course co-director of the biannual Harvard Shock Symposium, and has served as an evidence reviewer for the post cardiac arrest guidelines for the American Heart Association. In addition to his clinical duties and research, Dr. Cocchi’s administrative responsibilities include serving as the Director of Critical Care Quality for the Silverman Institute for Health Care Quality and Safety within the Department of Health Care Quality at BIDMC. In that role, he oversees all quality assurance-related matters, as well as quality improvement endeavors, across the 9 adult ICUs at BIDMC. He also serves as an Associate Medical Director for Boston MedFlight, an air and ground critical care transport service supporting the major teaching hospitals in Boston. A unifying theme of his clinical, research, and administrative work is improving the delivery of safe and high quality care to critically ill patients in the pre-hospital, ED and the ICU settings, in order to achieve improved outcomes for these most vulnerable patients.

Topics for Talks by Michael Cocchi

• Updates in post arrest care
• Proning in ARDS
• Management status epilepticus

Latest Publications

• Uber AJ, Perman SM, Cocchi MN, Patel PV, Ganley SE, Portmann JM, Donnino MW, Grossestreuer AV. Increased Heat Generation in Postcardiac Arrest Patients During Targeted Temperature Management Is Associated With Better Outcomes. Crit Care Med. 2018 Jul; 46(7):1133-1138.
• Moskowitz A, Grossestreuer AV, Berg KM, Patel PV, Ganley S, Casasola Medrano M, Cocchi MN, Donnino MW; Center for Resuscitation Science. The association between tidal volume and neurological outcome following in-hospital cardiac arrest. Resuscitation. 2018 Mar; 124:106-111.
• Chase M, Cocchi MN, Liu X, Andersen LW, Holmberg M, Donnino MW. Coenzyme Q10 in Acute Influenza. Influenza Other Respir Viruses. 2018 Aug: [Epub ahead of print].
• Law AC, Roche S, Reichheld A, Folcarelli P, Cocchi MN, Howell MD, Sands K, Stevens JP. Failures in the Respectful Care of Critically Ill Patients. Jt Comm J qual Patient Saf. 2018 Aug: [Epub ahead of print].
• Moskowitz A, Andersen LW, Huang DT, Berg KM, Grossestreuer AV, Marik PE, Sherwin RL, Hou PC, Becker LB, Cocchi MN, Doshi P, Gong J, Sen A, Donnino MW. Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation. Crit Care. 2018 Oct 29;22(1):283.
• Druwé P, Monsieurs KG, Piers R, Gagg J, Nakahara S, Alpert EA, van Schuppen H, Élő G, Truhlář A, Huybrechts SA, Mpotos N, Joly LM, Xanthos T, Roessler M, Paal P, Cocchi MN, BjØrshol C, Pauliková M, Nurmi J, Salmeron PP, Owczuk R, Svavarsdóttir H, Deasy C, Cimpoesu D, Ioannides M, Fuenzalida PA, Kurland L, Raffay V, Pachys G, Gadeyne B, Steen J, Vansteelandt S, De Paepe P, Benoit DD. Perception of inappropriate cardiopulmonary resuscitation by clinicians working in emergency departments and ambulance services: The REAPPROPRIATE international, multi-centre, cross sectional survey. Resuscitation. 2018 Nov;132:112-119.
• Murugappan KR, Cocchi MN, Bose S, Neves SE, Cook CH, Sarge T, Shaefi S, Leibowitz A. Case Study: Fatal Exertional Rhabdomyolysis Possibly Related to Drastic Weight Cutting. Int J Sport Nutr Exerc Metab. 2018 Sep 11:1-4. [Epub ahead of print]
• Karlsson CM, Donnino MW, Kirkegaard H, Cocchi MN, Chase M, Andersen LW. Acute Respiratory Compromise in the Emergency Department: A Description and Analysis of 3571 Events from the Get with the Guidelines-Resuscitation Registry. Journal of Emergency Medicine. 2017 Apr; 52(4):393-402.
• Moskowitz A, Omar Y, Chase M, Lockhandwala S, Chase M, Patel PV, Andersen LW, Cocchi MN, Donnino MW. Reasons for Death in Patients with Sepsis and Septic Shock. Journal of Critical Care. 2017 Apr;38:284-288.
• Donnino MW, Liu X, Andersen LW, Rittenberger JC, Abella BS, Gaieski D, Ornato J, Gazmuri RJ, Grossestreuer AV, Cocchi MN, Abbate A, Uber A, Clore J, Peberdy MA, Callaway CW. Characterization of Mitochondrial Injury after Cardiac Arrest (COMICA). Resuscitation. 2017 Apr;113:56-62.
• Nadler J, Stankovic N, Uber AJ, Holmberg MJ, Sanchez L, Chase M, Wolfe R, Donnino MW, Cocchi MN. Outcomes in variceal hemorrhage following the use of a balloon tamponade device. Am J Emerg Med. 2017 Oct;35(10):1500-1502.
• Moskowitz A, Andersen LW, Cocchi MN, Karlsson M, Patel PV, Donnino MW. Thiamine as a Renal Protective Agent in Septic Shock. A Secondary Analysis of a Randomized, Double-Blind, Placebo-controlled Trial. Ann Am Thorac Soc. 2017 May;14(5):737-741.
• Moskowitz A, Andersen LW, Karlsson M, Grossestreuer AV, Chase M, Cocchi MN, Berg K, Donnino MW. Predicting In-Hospital Mortality for Initial Survivors of Acute Respiratory Compromise (ARC) events: Development and Validation of the ARC Score. Resuscitation. 2017 Jun;115:5-10.
• Moskowitz A, Patel PV, Grossestreuer AV, Chase M, Shapiro NI, Berg K, Cocchi MN, Holmberg MJ, Donnino MW; Center for Resuscitation Science. Quick Sequential Organ Failure Assessment and Systemic Inflammatory Response Syndrome Criteria as Predictors of Critical Care Intervention Among Patients With Suspected Infection. Crit Care Med. 2017 Nov;45(11):1813-1819.
• Lokhandwala S, Andersen LW, Nair S, Patel P, Cocchi MN, Donnino MW. Absolute lactate value vs. relative reduction as a predictor of mortality in severe sepsis and septic shock. J Crit Care. 2017 Feb;37:179-184.
• Andersen LW, Liu X, Montissol S, Holmberg MJ, Sulmonte C, Balkema J, Cocchi MN, Gazmuri RJ, Berg K, Chase M. Cytochrome C in Patients with Septic Shock. Shock. 2016 May;45(5):512-517.
• Donnino MW, Andersen LW, Chase M, Berg K, Tidswell M, Giberson T, Wolfe R, Moskowitz A, Smithline H, Ngo L, Cocchi MN. Center for Resuscitation Science Research Group. Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study. Crit Care Med. 2016 Feb; 44(2):360-367.
• Moskowitz A, Andersen LW, Cocchi MN, Donnino MW. The Misapplication of Severity-of-Illness Scores Toward Clinical Decision Making. Am J Respir Crit Care Med. 2016 Aug; 194(3):256-258.
• Peberdy MA, Andersen LW, Abbate A, Thacker LR, Gaieski D, Abella BS, Grossestreuer AV, Rittenberger JC, Clore J, Ornato J, Cocchi MN, Callaway CW, Donnino MW. National Post Arrest Research Consortium (NPARC) Investigators. Inflammatory markers following resuscitation from out-of-hospital cardiac arrest-A prospective multicenter observational study. Resuscitation. 2016 Jun; 103:117-124.
• Donnino MW, Andersen LW, Berg K, Chase M, Sherwin R, Smithline H, Carney E, Ngo L, Patel PV, Liu X, Cutlip D, Zimetbaum P, Cocchi MN. collaborating authors from the Beth Israel Deaconess Medical Center’s Center for Resuscitation Science Research Group. Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial. Crit Care. 2016 Apr;20:82.
• Andersen LW, Holmberg MJ, Berg K, Chase M, Cocchi MN, Sulmonte C, Balkema J, MacDonald M, Montissol S, Senthilnathan V, Liu D, Khabbaz K, Lerner A, Novack V, Liu X, Donnino MW. Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial. Crit Care Med. 2016 Mar;20:92.
• Andersen LW, Kim WY, Chase M, Berg KM, Mortensen SJ, Moskowitz A, Novack V, Cocchi MN, Donnino MW; American Heart Association’s Get With the Guidelines(®) – Resuscitation Investigators. The prevalence and significance of abnormal vital signs prior to in-hospital cardiac arrest. Resuscitation. 2016 Jan; 98: 112-117.
• Andersen LW, Liu X, Montissol S, Holmberg MJ, Sulmonte C, Balkema JL, Cocchi MN, Gazmuri RJ, Berg KM, Chase M, Donnino MW. Cytochrome C in Patients with Septic Shock. Shock. 2016 May; 45(5):512-517.
• Andersen LW, Berg KM, Montissol S, Sulmonte C, Balkema J, Cocchi MN, Wolfe RE, Balasubramanyam A, Liu X, Donnino MW. Pyruvate dehydrogenase activity is decreased in emergency department patients with diabetic ketoacidosis. Acad Emerg Med. 2016 Jun;23(6):685-689.
• Donnino MW, Anderson LW, Chase M, Berg KM, Tidswell M, Giberson T, Wolfe R, Moskowitz A, Smithline H, Ngo L, Cocchi MN; Center for Resuscitation Science Research Group. Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study. Crit Care Med. 2016 Feb; 44(2):360-367.
• Peberdy MA, Andersen LW, Abbate A, Thacker LR, Gaieski D, Abella BS, Grossestreuer AV, Rittenberger JC, Clore J, Ornato J, Cocchi MN, Callaway C, Donnino M; National Post Arrest Research Consortium (NPARC) Investigators. Inflammatory markers following resuscitation from out-of-hospital cardiac arrest-a prospective multicenter observational study. Resuscitation. 2016 Jun; 103:117-124.
• Donnino MW, Andersen LW, Berg KM, Chase M, Sherwin R, Smithline H, Carney E, Ngo L, Patel PV, Liu X, Cutlip D, Zimetbaum P, Cocchi MN; Collaborating Authors from the Beth Israel Deaconess Medical Center’s Center for Resuscitation Science Research Group. Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial. Crit Care. 2016 Apr;20:82.
• Andersen LW, Holmberg MJ, Berg KM, Chase M, Cocchi MN, Sulmonte C, Balkema J, MacDonald M, Montissol S, Senthilnathan V, Liu D, Khabbaz K, Lerner A, Novack V, Liu X, Donnino MW. Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial. Crit Care. 2016 Mar;20:92.
• Andersen LW, Kurth T, Chase M, Berg KM, Cocchi MN, Callaway C, Donnino MW; American Heart Association’s Get With The Guidelines-Resuscitation Investigators. Early administration of epinephrine (adrenaline) in patients with cardiac arrest with initial shockable rhythm in hospital: propensity score matched analysis. BMJ. 2016 Apr; 353:i1577.
• Ikeda K, Liu X, Kida K, Marutani E, Hirai S, Sakaguchi M, Andersen LW, Bagchi A, Cocchi MN, Berg KM, Ichinose F, Donnino MW. Thiamine as a neuroprotective agent after cardiac arrest. Resuscitation. 2016 Aug;105:138-144.
• Andersen LW, Berg KM, Chase M, Cocchi MN, Massaro J, Donnino MW; American Heart Association’s Get With The Guidelines(®)-Resuscitation Investigators. Acute respiratory compromise on inpatient wards in the United States: incidence, outcomes, and factors associated with in-hospital mortality. Resuscitation. 2016 Aug;105:123-129.
• Moskowitz A, Andersen LW, Cocchi M, Donnino MW. The misapplication of severity-of-illness scores toward clinical decision making. Am J Respir Crit Care Med. 2016 Aug;194(3):256-258.
• Donnino MW, Andersen LW, Berg KM, Reynolds JC, Nolan JP, Morley P, Lang E, Cocchi MN, Xanthos T, Callaway C, Soar J; ILCOR ALS Task Force. Temperature Management After Cardiac Arrest: An Advisory Statement by the Advanced Life Support (ALS) Task Force of the International Liaison Committee on Resuscitation and the American Heart Association Emergency Cardiovascular Care Committee and the Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. Resuscitation. 2016 Jan;98:97-104.
• Giberson B, Uber AJ, Gaieski D, Miller J, Wira C, Berg K, Giberson TA, Cocchi MN, Abella BS, Donnino MW. When to stop CPR and when to perform rhythm analysis: Potential confusion among ACLS providers. J Intensive Care Med. 2016Sep;31(8):537-543.
• Andersen LW, Bivens MJ, Giberson T, Giberson B, Mottley JL, Gautam S, Salciccioli JD, Cocchi MN, McNally B, Donnino MW. The relationship between age and outcome in out-of-hospital cardiac arrest patients. Resuscitation. 2015 Sep;94:49-54.
• Lokhandwala S, Moskowitz A, Lawniczak R, Giberson T, Cocchi MN, Donnino MW. Disease heterogeneity and risk stratification in sepsis-related occult hypoperfusion: A retrospective cohort study. J Crit Care. 2015 Jun;30(3):531-536.
• Donnino MW, Mortensen SJ, Andersen LW, Chase M, Berg KM, Balkema J, Radhakrishnan J, Gazmuri RJ, Liu X, Cocchi MN. Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock – a randomized, double-blind, placebo-controlled pilot trial. Crit Care. 2015 Jul; 19:275.
• Nuzzo E, Berg KM, Andersen LW, Balkema J, Montissol S, Cocchi MN, Liu X, Donnino MW. Pyruvate dehydrogenase activity is decreased in the peripheral blood mononuclear cells of patients with sepsis: A prospective observational trial. Ann Am Thorac Soc. 2015 Nov;12(11):1662-1666.
• Donnino MW, Salciccioli JD, Howell MD, Cocchi MN, Giberson B, Berg K, Gautam S, Callaway CW. Time to administration of epinephrine and outcome after in-hospital cardiac arrest with non-shockable rhythms: retrospective analysis of large in-hospital data registry. BMJ. 2014 May;348:g3028.
• Cocchi MN, Boone MD, Giberson B, Giberson TA, Farrell E, Salciccioli JD, Talmor D, Williams D, Donnino MW. Fever after rewarming: Incidence of pyrexia in post-cardiac arrest patients who have undergone mild therapeutic hypothermia. J Intensive Care Med. 2014 Nov-Dec;29(6):365-369.
• Kim WY, Giberson TA, Uber AJ, Berg K, Cocchi MN, Donnino MW. Neurologic outcome in comatose patients resuscitated from out-of-hospital cardiac arrest with prolonged downtime and treated with therapeutic hypothermia. Resuscitation. 2014 Aug;85(8):1042-1046.
• Donnino MW, Andersen LW, Giberson T, Gaiski DF, Abella BS, Peberdy MA, Rittenberger JC, Callaway CW, Ornato J, Clore J, Grossestreuer A, Salccioli J, Cocchi MN; National Post-Arrest Research Consortium. Initial lactate and lactate change in post-cardiac arrest: a multicenter validation study. Crit Care Med. 2014 Aug;42(8):1804-1811.
• Flaherty SK, Weber RL, Chase M, Dugas AF, Graver AM, Salciccioli JD, Cocchi MN, Donnino MW. Septic shock and adequacy of early empiric antibiotics in the emergency department. J Emerg Med. 2014 Nov;47(5):601-607.
• Cristia C, Ho ML, Levy S, Andersen LW, Perman SM, Giberson T, Salciccioli JD, Saindon BZ, Cocchi MN. Donnino MW. The association between a quantitative computed tomography (CT) measurement of cerebral edema and outcomes in post-cardiac arrest – a validation study. Resuscitation. 2014 Oct;85(10):1348-1353.
• Salciccioli JD, Cocchi MN, Rittenberger JC, Peberdy MA, Ornato JP, Abella BJ, Gaieski DF, Clore J, Gautam S, Callaway CW, Donnino MW. Continuous neuromuscular blockade is associated with decreased mortality in post-cardiac arrest patients. Resuscitation. 2013 Dec;84(12):1728-1733.
• Omar Y, Massey M, Andersen LW, Giberson TA, Berg K, Cocchi MN, Shapiro NI, Donnino MW. Sublingual microcirculation is impaired in post-cardiac arrest patients. Resuscitation. 2013 Dec;84(12):1717-1722.
• Donnino MW, Salciccioli JD, Dejam A, Giberson T, Giberson B, Cristia C, Gautam S, Cocchi MN. APACHE II scoring to predict outcome in post-cardiac arrest. Resuscitation. 2013 May;84(5):651-656.
• Williams D, Calder S, Cocchi MN, Donnino MW. From door to recovery, a collaborative approach to the development of a post-cardiac arrest center. Crit. Care Nurse. 2013 Oct;33(5):42-54.
• Andersen LW, Mackenhauer J, Roberts JC, Berg KM, Cocchi MN, Donnino MW. Etiology and therapeutic approach to elevated lactate levels. Mayo Clin Proc. 2013 Oct;88(10):1127-40.
• Seigel TA, Cocchi MN, Salcicciolu J, Shapiro N, Howell M, Tang A, Donnino MW. Inadequacy of temperature and white blood cell count in predicting bacteremia in patients with suspected infection. J Emerg Med. 2012 Mar;42(3):254-259.
• Cox K, Cocchi MN, Salciccioli J, Carney E, Howell M, Donnino MW. Prevalence and significance of lactic acidosis in diabetic ketoacidosis. J Crit Care. 2012 Apr;27(2):132-137.
• Lucas JM, Cocchi MN, Salciccioli J, Stanbridge JA, Geocadin RG, Herman ST, Donnino MW. Neurologic recovery after therapeutic hypothermia in patients with Post-Cardiac arrest myoclonus. Resuscitation. 2012 Feb;83(2):265-9.
• Berg K, Lang J, Salciccioli J, Bak E, Cocchi MN, Gautam S, Donnino MW. The rapid shallow breathing index as a predictor of failure of noninvasive ventilation for patients with acute respiratory failure. Respir Care. 2012 Oct;57(10):1548-1554.
• Dugas AF, Mackenhaur J, Salciccioli JD, Cocchi MN, Gautam S, Donnino MW. Prevalence and characteristics of nonlactate and lactate expressors in septic shock. J Crit Care. 2012 Aug;27(4):344-350.
• Cocchi MN, Giberson B, Berg K, Salciccioli JD, Naini A, Buettner C, Akuthota P, Gautam S, Donnino MW. Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients. Resuscitation. 2012 Aug;83(8):991-995.
• Salciccioli JD, Cristia C, Chase M, Giberson T, Graver A, Gautam S, Cocchi MN, Donnino MW. Performance of SAPS II and SAPS III scores in post-cardiac arrest. Minerva Anestesiol. 2012 Dec;78(12):1341-1347.
• Donnino MW, Miller J, Bivens M, Cocchi MN, Salciccioli J, Farris S, Cutlip D, Howell M. A pilot study examining the severity and outcomes of the post-cardiac arrest syndrome: a comparative analysis of two geographically distinct hospitals. Circulation. 2012 Sep;126(12):1478-1483.
• Amesquita M, Cocchi MN, Donnino MW. Pulmonary embolism presenting as a flank pain: a case series. J Emerg Med. 2012 May;42(5):e97-100.
• Cocchi MN, Giberson B, Donnino MW. Rapid rewarming of hypothermic patient using arctic sun device. J Intensive Care Med. 2012 Mar-Apr; 27(2):128-30.
• Donnino MW, Miller JC, Bivens M, Cocchi MN, Salciccioli JD, Farris S, Gautam S, Cutlip D, Howell M. A pilot study examining the severity and outcome of the post-cardiac arrest syndrome: a comparative analysis of two geographically distinct hospitals. Circulation. 2012 Sep 18;126(12):1478-83.
• Hunziker S, Bivens MJ, Cocchi MN, Miller J, Salciccioli JD, Howell MD, Donnino MW. International validation of the Out-Of-Hospital Cardiac Arrest (OHCA) score in the United States. Crit Care Med. 2011 Jul;39(7):1670-1674.
• Cocchi MN, Miller J, Hunziker S, Carney E, Salciccioli JD, Farris S, Joyce N, Zimetbaum P, Howell MD, Donnino MW. The association of lactate and vaspressor need for mortality prediction in survivors of cardiac arrest. Minerva Anestesiol. 2011 Nov;77(11):1063-1071.
• Donnino MW, Cocchi MN, Salciccioli JD, Kim D, Naini A, Buettner C, Akuthota P. Coenzyme Q10 levels are low and are associated with the inflammatory cascade in septic shock. Crit Care. 2011 Aug;15(4):R189.
• Donnino MW, Cocchi MN, Miller J, Fisher J. Cannabinoid hyperemesis: a case series. J Emerg Med. 2011 Apr;40(4):e63-6.
• Donnino MW, Cochi MN, Salciccioli JD, Kim D, Naini AB, Buettner C, Akuthota P. Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock. Crit Care. 2011 Aug 9; 15(4):R189.
• Donnino MW, Rittenberger JC, Gaieski D, Cocchi MN, Giberson B, Peberdy MA, Abella BS, Bobrow BJ, Callaway C. The development and implementation of cardiac arrest centers. Resuscitation. 2011 Aug;82(2):974-8.
• Donnino MW, Carney E, Cocchi MN, Barbash I, Chase M, Joyce N, Chou PP, Ngo L. Thiamine deficiency in critically ill patients with sepsis. J Crit Care. 2010 Dec; 25(4):576-581.
• Cocchi MN, Lucas J, Salciccioli J, Carney E, Herman S, Zimetbaum P, Donnino MW. The role of cranial computed tomography in the immediate post-arrest period. Intern Emerg Med. 2010 Dec;5(6):533-538.
• Donnino MW, Cocchi M, Smithline H, Carney E, Chou PP, Salciccioli JD. Coronary Artery Bypass Graft surgery depletes plasma thiamine levels. Nutrition. 2010 Jan;26(1):133-136.
• Donnino MW, Cocchi MN, Howell M, Clardy P, Talmor D, Cataldo L, Chase M, Al-Marshad A, Ngo, L, Shapiro NI. Statin therapy is associated with decreased mortality in patients admitted with infection. Acad Emerg Med. 2009 Mar;16(3):230-234.
• Cocchi MN, Kimlin E, Walsh M, Donnino MW. Identification and resuscitation of the trauma patient in shock. Emerg Med Clin North Am. 2007 Aug;25(3):623-42.