July 2023 – New Accepted Study! Kidney-Specific Biomarkers for Predicting Acute Kidney Injury Following Cardiac Arrest
In post-cardiac arrest patients, creatinine, NGAL, and cystatin-C measured shortly after ROSC were higher in patients who subsequently developed AKI. No single biomarker was statistically superior to creatinine for predicting the development of post-arrest AKI.
Congratulations to the authors!
Berlin N, Pawar RD, Liu X, Balaji L, Morton AC, Silverman J, Li F, Issa MS, Roessler LL, Holmberg MJ, Shekhar AC. Kidney-Specific Biomarkers for Predicting Acute Kidney Injury Following Cardiac Arrest. Resuscitation. 2023 Jul 25:109911.
Read more: Link to the study
November 2022 – Medical Grand Rounds recognizing Dr. Michael Donnino
Congratulations to Dr. Michael Donnino for being recognized and promoted as a Professor in Medicine at Harvard Medical School in the Medical Grand Rounds. To read more about it – Read here
To watch the Grand Rounds Talk – Click here!
November 2022 – Dr Donnino featured in the Annals of Internal Med Podcast!
In this episode of Annals On Call, Dr. Centor discusses the underuse of thiamine in critically ill patients with alcohol use disorder with Dr. Michael Donnino. Annals articles discussed include the Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness. A Nationwide Retrospective Observational Study: https://www.acpjournals.org/doi/10.7326/M21-2103
Here is the link to listen – https://www.acpjournals.org/doi/10.7326/A21-0023#.Y3LJ1Y8cLhw.twitter
June 9th 2022 – Inflammatory Biomarkers in Dogs Post-Cardiac Arrest – A New Observational Pilot Study
Congratulations to our T32 fellow, Dr. Noa Berlin, for successfully obtaining a grant to study the inflammatory changes in pet dogs who have experienced natural cardiac arrest and compare it to people with similar conditions.
Supported by the American College of Veterinary Emergency and Critical Care (ACVECC) and the Reassessment Campaign on Veterinary Resuscitation (RECOVER) Initiative, we are excited to be collaborating with Tufts University on this pilot study, which will lay the groundwork for future translational research projects, in which dogs with naturally-occuring conditions can be used as models for human resuscitation research, and help advance both veterinary-and human medicine. We are excited for further collaborations in this field!
December 27th 2021 – New Accepted Study: Esmolol To Treat The Hemodynamic Effects of Septic Shock: A Randomized Controlled Trial
In our study of 40 patients with septic shock and tachycardia, we tested whether esmolol would reduce the need for vasopressors at 6h compared to placebo, as well as other outcomes. We found that there was no difference in vasopressor use at 6h or shock-free days between groups, but there were lower levels of C-reactive protein at 12 and 24 h in the esmolol arm, as well as a difference in trend over time between groups; there was no difference in levels of IL-4, IL-6, IL-10, and TNFα. We also found decreased oxygen consumption in the subset of patients who underwent VO2 monitoring when comparing esmolol to placebo. Here is the link to the study