December 27th 2021 – New Accepted Study: Esmolol To Treat The Hemodynamic Effects of Septic Shock: A Randomized Controlled Trial
In our study of 40 patients with septic shock and tachycardia, we tested whether esmolol would reduce the need for vasopressors at 6h compared to placebo, as well as other outcomes. We found that there was no difference in vasopressor use at 6h or shock-free days between groups, but there were lower levels of C-reactive protein at 12 and 24 h in the esmolol arm, as well as a difference in trend over time between groups; there was no difference in levels of IL-4, IL-6, IL-10, and TNFα. We also found decreased oxygen consumption in the subset of patients who underwent VO2 monitoring when comparing esmolol to placebo. Here is the link to the study
December 7th 2021 – New Accepted Study: Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness: A Nationwide Retrospective Observational Study
Thiamine deficiency can cause irreversible brain damage if left untreated. Alcohol use is the most common risk factor of thiamine deficiency. Thiamine supplementation, the mainstay of treatment of thiamine deficiency, is safe, effective, and recommended by different scientific organizations while caring for patients with alcohol use. Despite that, thiamine supplementation is underutilized. We describe the incidence of thiamine supplementation in patients with alcohol use disorder admitted to ICU using the Cerner Database, a nationally representative dataset. We found that almost half such patients did not receive even a single dose of thiamine. Read more about this in our article published in Annals of Internal Medicine. Here is the link to the study
Congrats to the authors on another publication!
The authors are happy to contribute to the research on Covid-19 with their recently published study: Viral load and disease severity in COVID‑19
The CRS Welcomes New Interns!
The Center for Resuscitation Science is excited to have two new research interns: Maria Cabrera and Soumya Malhotra! Welcome, Maria and Soumya, we are excited to have you on the team!
Congrats to the author team for the recent publication! January 21, 2021
The authors are excited to announce the recent publication of the latest publication: Lactate and hypotension as predictors of mortality after in-hospital cardiac arrest.