About Xiaowen Liu
Dr. Liu’s research is focused on human nutritional and metabolic dysfunction in the critically ill patients. After completing 6 years of the Interdepartmental Graduate Program in Nutritional Sciences and statistics in university of Wisconsin- Madison, and 3.5 years of postdoctoral training in endocrinology at Beth Israel Deaconess Medical Center, Harvard Medical School, Dr. Liu has developed an area of expertise in basic science research, biostatistics and data analysis which is critical for success in translational research. After completion of my post-doctoral training, I became the Lab Director at the Center for Resuscitation Science in BIDMC, which is a multi-disciplinary group of investigators focused on translational research with an emphasis on metabolic and mitochondrial dysfunction in the critically ill. As laboratory director I am providing an excellent bridge between clinical investigation and basic science. My research on immunocapture and microplate-based activity and quantity measurement of pyruvate dehydrogenase in human peripheral blood mononuclear cells set is a novel, easy and less invasive way to further understand the role of PDH, a key enzyme linking the glycolysis metabolic pathway to the citric acid cycle and releasing energy via NADH, in human disease. My current work is focused on evaluating mitochondrial and metabolic dysfunction across a range of critical illness and the response to potential metabolic resuscitators both in the lab and clinical setting.
Latest Publications
- Fagerberg SK, Patel P, Andersen LW, Lui X, Donnino MW, Praetorius HA. Erythrocyte P2X1 receptor expression is correlated with change in haematocrit in patients admitted to the ICU with blood pathogen-positive sepsis. Crit Care. 2018 Aug; 22(1):181.
- Holmberg MJ, Uber A, Stankovic N, Chen CO, Grossestreuer AV, Donnino MW, Andersen LW, Liu X. Ubiquinol (Reduced Coenzyme Q10) and Cellular Oxygen Consumption in Patients Undergoing Coronary Artery Bypass Grafting. J Intensive Care Med. 2018 Jan:[Epub ahead of print].
- Liu X, Montissol S, Uber A, Ganley S, Grossestreuer AV, Berg K, Heydrick S, Donnino MW. The Effects of Thiamine on Breast Cancer Cells. Molecules. 2018 Jun; 23(6).
- Chase M, Cocchi MN, Liu X, Andersen LW, Holmberg M, Donnino MW. Coenzyme Q10 in Acute Influenza. Influenza Other Respir Viruses. 2018 Aug: [Epub ahead of print].
- Donnino MW, Liu X, Andersen LW, Rittenberger JC, Abella BS, Gaieski D, Ornato J, Gazmuri RJ, Grossestreuer AV, Cocchi MN, Abbate A, Uber A, Clore J, Peberdy MA, Callaway CW. Characterization of Mitochondrial Injury after Cardiac Arrest (COMICA). Resuscitation. 2017 Apr;113:56-62.
- Andersen LW, Liu X, Montissol S, Holmberg MJ, Fabian-Jessing BK, Donnino MW; Center for Resuscitation Science Research Group. Cytochrome c in patients undergoing coronary artery bypass grafting: A post hoc analysis of a randomized trial. J Crit Care. 2017 Dec;42:248-254.
- Andersen LW, Liu X, Montissol S, Holmberg MJ, Sulmonte C, Balkema J, Cocchi MN, Gazmuri RJ, Berg K, Chase M. Cytochrome C in Patients with Septic Shock. Shock. 2016 May;45(5):512-517.
- Donnino MW, Andersen LW, Berg K, Chase M, Sherwin R, Smithline H, Carney E, Ngo L, Patel PV, Liu X, Cutlip D, Zimetbaum P, Cocchi MN. collaborating authors from the Beth Israel Deaconess Medical Center’s Center for Resuscitation Science Research Group. Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial. Crit Care. 2016 Apr;20:82.
- Andersen LW, Holmberg MJ, Berg K, Chase M, Cocchi MN, Sulmonte C, Balkema J, MacDonald M, Montissol S, Senthilnathan V, Liu D, Khabbaz K, Lerner A, Novack V, Liu X, Donnino MW. Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial. Crit Care Med. 2016 Mar;20:92.
- Andersen LW, Liu X, Montissol S, Holmberg MJ, Sulmonte C, Balkema JL, Cocchi MN, Gazmuri RJ, Berg KM, Chase M, Donnino MW. Cytochrome C in Patients with Septic Shock. Shock. 2016 May; 45(5):512-517.
- Andersen LW, Berg KM, Montissol S, Sulmonte C, Balkema J, Cocchi MN, Wolfe RE, Balasubramanyam A, Liu X, Donnino MW. Pyruvate dehydrogenase activity is decreased in emergency department patients with diabetic ketoacidosis. Acad Emerg Med. 2016 Jun;23(6):685-689.
- Donnino MW, Andersen LW, Berg KM, Chase M, Sherwin R, Smithline H, Carney E, Ngo L, Patel PV, Liu X, Cutlip D, Zimetbaum P, Cocchi MN; Collaborating Authors from the Beth Israel Deaconess Medical Center’s Center for Resuscitation Science Research Group. Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial. Crit Care. 2016 Apr;20:82.
- Andersen LW, Holmberg MJ, Berg KM, Chase M, Cocchi MN, Sulmonte C, Balkema J, MacDonald M, Montissol S, Senthilnathan V, Liu D, Khabbaz K, Lerner A, Novack V, Liu X, Donnino MW. Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial. Crit Care. 2016 Mar;20:92.
- Ikeda K, Liu X, Kida K, Marutani E, Hirai S, Sakaguchi M, Andersen LW, Bagchi A, Cocchi MN, Berg KM, Ichinose F, Donnino MW. Thiamine as a neuroprotective agent after cardiac arrest. Resuscitation. 2016 Aug;105:138-144.
- Liu X, Pervez H, Andersen LW, Uber AJ, Montissol S, Patel PV, Donnino MW. Microplate-based activity measurement of pyruvate dehydrogenase in human blood mononuclear cells. Bioanalysis. 2015;7(5):583-592.
- Andersen LW, Liu X, Peng TJ, Giberson TA, Khabbaz KR, Donnino MW. Pyruvate dehydrogenase activity decreases after coronary artery bypass grafting: a prospective observational study. Shock. 2015 Mar; 43(3)250-254.
- Liu X, Pervez H, Andersen LW, Uber A, Montissol M, Patel P, Donnino MW. Immunocapture and microplate-based activity measurement of pyruvate dehydrogenase in human blood mononuclear cells. Bioanalysis. 2015;7(5):583-592.
- Donnino MW, Mortensen SJ, Andersen LW, Chase M, Berg KM, Balkema J, Radhakrishnan J, Gazmuri RJ, Liu X, Cocchi MN. Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock – a randomized, double-blind, placebo-controlled pilot trial. Crit Care. 2015 Jul; 19:275.
- Nuzzo E, Berg KM, Andersen LW, Balkema J, Montissol S, Cocchi MN, Liu X, Donnino MW. Pyruvate dehydrogenase activity is decreased in the peripheral blood mononuclear cells of patients with sepsis: A prospective observational trial. Ann Am Thorac Soc. 2015 Nov;12(11):1662-1666.
- Moskowitz A, Graver AM, Giberson TA, Berg K, Liu X, Uber AJ, Gautam S, Donnino MW. The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis. J Crit Care. 2014 Feb;29(1):182.e5-8.